Results of a workshop on the research needs related to problems of exposure to toxic materials, their metabolism in the human body, and their mechanisms of toxic action were presented. The participants suggested a high priority be given to implementing and continuing operation of the National Death Index under the National Center for Health Statistics. Legal impediments which current block both federal and nonfederal epidemiology research should be investigated. Recommendations arising from the subgroup dealing with epidemiology included identification of problems in securing federal data system information, the need for epidemiological studies of human reproduction, and efforts to quantify exposure and response relationships. Recommendations from the area on quantification of information concerned the multidisciplinary approach to disease, use of biological monitoring of the environment through animal diseases and other natural sentinels, sharing and integrating data bases, geochemical aspects of the problem, and multimedia approaches. The group on methods of monitoring individual exposure to environmental pollutants stressed the importance of methods development, development of quality assurance programs for data collection, and the environmental monitoring of emergencies. Those involved with metabolic studies suggest emphasis on genetic traits, pharmacokinetic parameters, metabolic pathways and kinetics of drug metabolizing enzymes, mathematical models of carcinogenesis, and long range support for predictions of interactions between chemicals and receptor sites. Those concerned with in-vivo toxicity suggest emphasis on teratology research, genetic effects, respiratory tract disease, toxicological interactions, and passive smoking. Those dealing with mechanisms of toxicity and carcinogenicity urged more studies on promotion of carcinogenesis and replication of genetic material, somatic mutation rate studies, quantification of somatic mutation rates, and measures of accumulations of DNA adducts and DNA damage.
Proceedings of the Second NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, September 9-11, 1981, Rockville, Maryland