Occupational risks of pesticide exposure for females.
Department of Anatomy, Louisiana State University Medical Center, New Orleans, Louisiana 1988 Nov; :1-31
The effects of a reproductive toxicant on the ovary and ovulatory ability of mice as well as on the embryological development of the ovaries of mice exposed before birth to the same toxic agent were investigated. Specific attention was given to the effect of these agents on steroid hormone levels, specific follicle populations and cell surface characteristics of the various cellular components making up the ovary. Virgin female CD-1-mice were exposed to 0.062, (0.1mg), or sesame oil (control group) in a 0.2 milliliter (ml) volume by oral gavage. Significant decreases in the ovulatory response of the ovaries were noted after 4 to 6 weeks of exposure to chlordecone when compared to the other two study groups. It is thought that this decrease resulted from an increase in the number of athletic large follicles following the 4 week exposure which caused there to be no ready pool of follicles to ovulate in response to the gonadotropins. A significant increase was noted in the livers of chlordecone exposed mice, increasing in a linear fashion from 2 to 6 weeks of exposure. During this time chlordecone was accumulated by the liver. No external malformations or deviations from the normal sex ratio were seen to result from chlordecone exposure. Vaginal openings were noted in the female offspring of treated mice at significantly earlier times than for those from nontreated animals. This was also true for female offspring of the second litter to be born after the exposure of the mother.
NIOSH-Grant; Reproductive-system-disorders; Agricultural-chemicals; Insecticides; Laboratory-animals; Reproductive-hazards; Toxic-effects
Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
Final Grant Report
NTIS Accession No.
Department of Anatomy, Louisiana State University Medical Center, New Orleans, Louisiana
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana