Occupational health hazards in skin injury by mitomycin C.
Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania 1988 Nov; :1-30
The incidence of cutaneous intradermal injuries resulting from exposure to mitomycin-C (50077) (MMC) was studied. Dehaired mice received topical MMC intradermal injections followed by various topical antidotal treatments. Skin toxicity studies demonstrated a dose dependent toxicity with MMC exposures. Within 1 to 5 days following injection, ulcers appeared with induration and erythema 20 and 10 fold greater in size than was the central ulcer, respectively. By day five, erythema tended to peak and then resolve over a 2 to 4 week period. Induration also peaked at day five but remained visible up to 7 weeks. Ulcers due to MMC exposure had a central necrotic appearance and resembled adriamycin induced ulcers. While larger doses did not produce correspondingly larger ulcers, they did require longer periods of time to heal. For most of the pharmacologic agents tested, no antidotal activity was noted. Marked antidotal activity was observed following topical administration of dimethylsulfoxide, with complete protection against MMC ulceration being provided following a low dose application. For high dose MMC, a single topical application of DMSO immediately after MMC was most effective. Some therapeutic benefit was derived from treatment with sodium-thiosulfate, but this was much less than that obtained with DMSO therapy.
NIOSH-Grant; Dermatitis; Antineoplastic-agents; Medical-treatment; Skin-exposure; Skin-irritants; Laboratory-animals
Medicine University of Pittsburgh 922 Scaife Hall Pittsburgh, PA 15261
Final Grant Report
NTIS Accession No.
Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania
University of Pittsburgh, Pittsburgh, Pennsylvania