Induction of neonatal rat skin and liver aryl hydrocarbon hydroxylase by coal tar and its constituents.
Bickers-DR; Wroblewski-D; Dutta-Choudhury-T; Mukhtar-H
J Invest Dermatol 1982 Mar; 78(3):227-229
The effects of coal-tar (8007452) and selected, defined, purified constituents of therapeutic coal tar on skin and liver aryl- hydrocarbon-hydroxylase (AHH) activity of neonatal rats were investigated. Application of coal-tar solution to neonatal rats 24 hours prior to sacrifice induced skin and liver AHH 15 and eight fold respectively. AHH induction in isolated epidermis and dermis was ten and 18 fold over the corresponding control values. Application of coal-tar to the skin of pregnant rats resulted in induction of skin and liver AHH activity in both mothers and prenatal rats. Coal-tar fumes induced skin and liver enzyme activities in the control animals housed adjacent to the exposed animals, but to a significantly less extent. Among the several defined constituents of coal-tar were some with measurable induction effects including benzo(a)pyrene (50328) (BP), anthracene (120127) and acridine (260946). These findings suggested that for therapeutic purposes it would be desirable to remove those constituents of coal-tar with potentially toxic and/or carcinogenic effects such as BP. Ideally these could be selectively extracted while maintaining the therapeutic efficacy of the coal tar.
NIOSH-Publication; NIOSH-Grant; Dermatitis; Laboratory-animals; Skin-exposure; Skin-absorption; Liver-enzymes; Enzyme-activity; Therapeutic-agents; Polycyclic-aromatic-hydrocarbons; Carcinogens
Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
8007-45-2; 50-32-8; 120-12-7; 260-94-6
Journal of Investigative Dermatology
Case Western Reserve University, Cleveland, Ohio