Elevated blood pressure in treated hypertensives with low-level lead accumulation.
Sharp DS; Smith AH; Holman BL; Fisher JM; Osterloh J; Becker CE
Arch Environ Health 1989 Feb; 44(1):18-22
An analysis was conducted to assess the relationship between blood lead (7439921) levels (PbB) and blood pressure (BP) in bus drivers treated for hypertension. The sample group included 51 drivers who appeared to be representative of the target population and who were undergoing treatment for hypertension; 33 with primarily diuretics only and 18 with beta blockers. Concentrations of blood lead among these individuals ranged from 2 to 24 micrograms/deciliter (microg/dl). The adjusted regression coefficients relating systolic BP to PbB were -6.4 and 4.5mmHg/natural log(microg/dl) (mmHg/ln(microg/dl)) for the diuretic and beta blocker groups, respectively. The adjusted coefficients for diastolic BP were 1.11 and 14.3mmHg/ln(microg/dl) for the diuretic and beta blocker groups, respectively. The latter relationship represented an average increment of 12mmHg in diastolic BP over the range of observed blood lead levels in subjects treated with beta blockers. The authors conclude that beta blocker treatment may be less effective in reducing diastolic pressure in individuals with higher blood lead levels. The results suggest an action of lead at PbBs below current standards.
NIOSH-Publication; Lead-poisoning; Blood-analysis; Bus-drivers; Transportation-workers; Exhaust-gases; Blood-pressure; Medical-treatment
Archives of Environmental Health
University Of California, Berkeley