Acute airway narrowing in monkeys from challenge with 2.5 PPM formaldehyde generated from formalin.
Biagini-RE; Moorman-WJ; Knecht-EA; Clark-JC; Bernstein-IL
Arch Environ Health 1989 Jan; 44(1):12-17
A simple method was developed for generating controlled, stable levels of formaldehyde (50000) vapor from formalin and efforts were then made to determine if bronchial challenge for 10 minutes with 2.5 parts per million (ppm) formaldehyde produced pulmonary functional deficits in Cynomolgus-monkeys (Macaca-fascicularis). The experimental design included preexposure methacholine challenge to determine if responses to formaldehyde were associated with preexisting bronchial hyperreactivity. There was a 2 week interval between methacholine and formaldehyde challenges. Methacholine challenge produced statistically significant increased in average pulmonary flow resistance at all challenge concentrations. The 10 minute formaldehyde challenge caused significant increases in pulmonary flow resistance within 2 minutes which were still evident at 5 and 10 minutes post challenge. Formaldehyde airway narrowing in these animals was not correlated to methacholine airway reactivity, even though the small number of animals used may have precluded the observation of a statistically significant association.
NIOSH-Author; Pulmonary-system-disorders; Laboratory-animals; Airway-resistance; Toxic-gases; Inhalation-studies; Pulmonary-function-tests; Lung-function; Aldehydes
Archives of Environmental Health