Galactose inhibition of ovulation in mice.
Fertil Steril 1988 Mar; 49(3):522-526
Efforts were undertaken to determine whether a diet containing galactose would interfere with ovulation. Female NIH-white-mice were maintained on a 50 percent galactose diet for either 2, 4, or 6 weeks at which time the animals were sacrificed. Other groups of mice were also placed on this diet for similar time periods and then exposed to a superovulatory regimen of gonadotropins. An additional group was kept on the diet for 7 weeks and then returned to a regular mouse laboratory chow for 1 week. No abnormal alterations in body weights were noted among the various groups. Animals on the galactose diet exhibited a decrease in their normal ovulatory response. Mice on the diet for 2 weeks contained ovaries with a mean of less than 1 corpus luteum, compared with the 11.4 for the control group. Mice placed on the diet for 7 weeks and then on normal mouse chow for a week contained ovaries with corpora lutea approaching control levels, demonstrating the reversibility of the condition. Mice induced to superovulate with exogenous gonadotropin administration demonstrated an ovulatory response significantly reduced when compared to that of the control group, indicating that the diet of galactose prevented not only the normal ovulatory response but also blocked the superovulatory response to exogenous gonadotropins.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Laboratory-animals; Fertility; Dietary-effects; Hormones; Sugars; Reproductive-effects
Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
Fertility and Sterility
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana