Chronobiometry with pocket calculators and computer systems.
Cornelissen-G; Halberg-F; Stebbings-J; Halberg-E; Carandente-F; Hsi-B
Ricerca in Clinica e in Laboratorio 1980 Apr; 10(2):333-385
A review was made of selected methods for the study of biologic time series, including instrumentation and numerical methods. The relative merits of these methods were considered in the light of underlying assumptions. Examples of the usefulness of these methods in several fields of biology and medicine were provided. An investigation was included of the monitoring of environmental integrity, particularly of environmental pollution. The need for specifying optimal sampling requirements was underlined. The establishment of reference intervals was examined as required for increasingly rational individualized programs from the prevention and/or the treatment of disease using an individualized and time qualified definition of health. The authors indicate that once the reference intervals and rhythm characteristics are available, a better interpretation can be made with single samples or time series of an impending increased risk of a certain disease or the inception of the disease. The monitoring of environmental and/or personal marker rhythms is essential for all of these aims as it is necessary to obtain large data bases from which information can be more easily derived for monitoring personal health, to recognize risk as well as to diagnose disease early and to optimize treatment by timing according to rhythms. An appendix included programs for the single and population mean cosinor procedures for use on a TI-59 pocket calculator
NIOSH-Publication; NIOSH-Grant; Psychological-disorders; Sampling-methods; Biological-monitoring; Environmental-health-monitoring; Monitoring-systems; Circadian-rhythms; Age-factors; Measurement-equipment
Lab Medicine and Pathology University of Minnesota 380 Lyon Laboratories Minneapolis, MN 55455
Ricerca in Clinica e in Laboratorio
University of Minnesota of Mnpls-St Paul, Minneapolis, Minnesota