Testing for behavioral effects of agents.
Proceedings of the Workshop on Test Methods for Definition of Effects of Toxic Substances on Behavior and Neuromotor Function, April 1-4, 1979, San Antonio. Texas. Geller I, Stebbins WC, Wayner MJ, eds., Fayetteville, NY: Ankho International, 1979 Apr; :119-127
Reasons for studying the behavioral effects of toxic agents were discussed. Behavioral toxicology may be important in the determination of the effects of exposure to various chemical agents as changes in behavior may be evident long before morphological or chemical changes may be detectable by other analytical methods. An example was given to demonstrate the usefulness of behavioral toxicology in a teratology study of mice. In this study the effects of atropine (51558) or caffeine (58082) were examined throughout the period of central nervous system development. The finding of the study was that no behavioral effects were detected at caffeine exposures of less than those which also caused reduced viability of the fetuses and infants. This cannot be taken to mean that caffeine is not a behavioral teratogen at doses less than this level. From reported and observed variability it is surmised that changes that occur in as many as 1 per 100 of the population or average as large as a 10 percent decrement will still be too small to be detected by direct experimentation. These risks are often unacceptable and yet it is hard in blind testing to establish in animals incidences as high as 1 in 100 or declines as great as 10 percent. The authors indicate that epidemiological studies may be able to supplement experimental toxicology to provide a better assessment of risk of small impairments or rare susceptibility.
NIOSH-Grant; Grants-other; Laboratory-animals; Behavioral-disorders; Behavioral-testing; Epidemiology; Risk-analysis; Embryotoxicity; Teratogenicity
Psychiatry Harvard Medical School 25 Shattuck Street Boston, Mass 02115
Geller-I; Stebbins-WC; Wayner-MJ
Other Occupational Concerns; Grants-other
Proceedings of the Workshop on Test Methods for Definition of Effects of Toxic Substances on Behavior and Neuromotor Function, April 1-4, 1979, San Antonio. Texas
Harvard University, Boston, Massachusetts