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Circadian rhythms in cell proliferation: their importance when investigating the basic mechanism of normal versus abnormal growth.
Eleventh International Congress of Anatomy: Biological Rhythms in Structure and Function. Acosta Vidrio E, ed., New York: A. R. Liss, 1981 Jan; :39-79
The history of research on cell division rhythms for plants and animals was reviewed including results of studies of the mitotic index rhythm in the bone marrow from young men, the mitotic index rhythm in the epidermis of the adult man, liver regeneration in animals, and the mitotic index in the epidermis of the pinna of the rat. All cell division rhythms were synchronized to the light dark cycle if the animals were fed ad libitum. Some rhythms could be manipulated by restricting feedings to a particular time of the day. Some of these included cell division in the bone marrow, spleen and intestinal tract. Drugs may also be used to alter the rhythm of the mitotic index. Even with all the studies, the mechanism of cell division and its associated rhythmicity has not been fully understood. According to the author, understanding these rhythms is important since there are also rhythms in the toxicity of any drug which has as its target any specific phase of the cell cycle. Such variations in susceptibility to several anticancer agents which are cell cycle specific can be optimized in experimental cancer chemotherapy.
NIOSH-Grant; Neurotoxic-effects; Pharmacodynamics; Humans; Laboratory-animals; Medical-treatment; Drug-interaction; Drug-therapy; Antineoplastic-agents
Anatomy University of Arkansas 4301 West Markham Little Rock, Ark 72201
Neurotoxic Disorders; Neurotoxic-effects
Eleventh International Congress of Anatomy: Biological Rhythms in Structure and Function, A. R. Liss, Inc., New York, New York
University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
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