Pulmonary and immunologic evaluation of foundry workers exposed to methylene diphenyldiisocyanate (MDI).
Liss-GM; Bernstein-DI; Moller-DR; Gallagher-JS; Stephenson-RL; Bernstein-IL
J Allergy Clin Immunol 1988 Jul; 82(1):55-61
Occupational symptoms were assessed in steel workers at a foundry in Ohio in which methylene-diphenyldiisocyanate (101688) (MDI) was used for making cores and molds. The study population consisted of three groups of workers: 26 men currently employed in the core and mold area and regularly exposed to MDI; six workers previously in the core and mold areas but now working in other departments with no MDI exposures; and 14 workers who had never been exposed to MDI. Significant clinical respiratory and immune responses were found in foundry workers exposed to MDI. These abnormalities were not detected in workers who had not been directly exposed to MDI. MDI/human serum albumin (HSA) specific humoral responses were detected only in workers currently or formerly exposed. Because immunoglobulin-G and total specific antibodies to MDI-HSA were detected in symptomatic as well as asymptomatic workers, these immune responses may simply reflect significant prior MDI exposure. Elevated specific immunoglobulin-E against MDI-HSA was noted in one currently exposed worker and was associated with clinical symptoms of immediate onset asthma, rhinitis, and conjunctivitis. He may have been exposed during an accidental spill at the factory to peak exposures of MDI. He did react positively to a cutaneous prick test to MDI-HSA and hexamethylene-diisocyanate/HSA conjugates. ELISA was determined to be a sensitive but nonquantifiable assay for detecting antibody responses against MDI-HSA in this group of workers. Specific immunoglobulin-G to MDI-HSA did not discriminate between asymptomatic workers and those reporting asthmatic symptoms.
NIOSH-Author; Isocyanates; Pulmonary-system-disorders; Immune-reaction; Steel-industry; Steel-foundries; Diagnostic-techniques; Immune-system; Immunoglobulins; Antibody-response
Journal of Allergy and Clinical Immunology