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Transdermal drug delivery: a perspective.
Guy RH; Hadgraft J
J Control Release 1987 Feb; 4(4):237-251
The use of transdermal drug delivery as a method for systemic drug administration was reviewed. Advantages of transdermal drug delivery included patient compliance, simplicity of administration, immediate reduction of plasma levels of the drug upon removal of the device, reduction in drug related side effects, maintenance of sustained controllable drug levels in the plasma, and elimination of first pass metabolism. The primary limitations of the method were the barrier properties of the skin and potential inflammatory or allergic reactions due to drug bioactivity. The four drugs approved for transdermal delivery in the United States, clonidine, estradiol, nitroglycerin, and scopolamine, and two drugs under experimental review for transdermal methodology, nicotine and timolol, were described. Discussion focused on the physicochemical properties of the drugs and percutaneous absorption modelling in relation to optimal conditions for successful transdermal delivery and problems relating to skin sensitivity, cutaneous metabolism, and tolerance.
NIOSH-Publication; NIOSH-Grant; Dermatitis; Skin-absorption; Drug-therapy; Medical-treatment; Pharmaceuticals; Pharmacodynamics; Therapeutic-agents; Biokinetics
Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
Issue of Publication
Journal of Controlled Release
University of California San Francisco, San Francisco, California
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division