Shortened forms of provocative lead chelation.
Sokas-RK; Atleson-J; Keogh-JP
J Occup Med 1988 May; 30(5):420-424
Timed fractional urine lead (7439921) measurements were performed following provocative chelation therapy among 41 men with and without known past lead exposure. All of the subjects had serum creatinine levels of less than 2 milligrams per milliliter. Each patient received a 1 hour intravenous infusion of 1 gram of CaNa2- EDTA in dextrose solution, and urine samples were collected upon initiation of the infusion and at 3, 6, and 24 hours following the start of the infusion. The 3 and 6 hour urine lead tests correlated linearly with the standard two dose 24 hour urine lead tests with respective correlation coefficients of 0.89 and 0.94. The sensitivity of the 3 and 6 hour urine lead measurements were 76 percent and 82 percent respectively when the 24 hour value of 600 micrograms of lead was used as the cutoff for high lead excretion. The respective specificities of the two determinations were 95 and 100 percent using the same cutoff value. Serum creatinine levels among ten well controlled hypertensive patients did not vary significantly during an observation period of approximately 10 months following the chelation therapy. The results were discussed in relation to various biologic markers of lead toxicity including whole blood lead and zinc-protoporphyrin levels and the potential risks of diagnostic chelation. The authors suggest that shortened chelation therapy may be useful in patients with uncertain exposures and for epidemiologic studies.
JOCMA7; NIOSH-Publication; NIOSH-Grant; Cardiovascular-system-disorders; Heavy-metals; Trace-analysis; Urinalysis; Medical-treatment; Chelating-agents; Lead-poisoning; Humans
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Journal of Occupational Medicine
University of Pennsylvania, Philadelphia, Pennsylvania