Neurotoxic fragrance produces ceroid and myelin disease.
Spencer-PS; Sterman-AB; Horoupian-DS; Foulds-MM
Science 1979 May; 204(4393):633-645
The neurotoxic changes occurring in rats exposed to the musk fragrance, acetyl-ethyl-tetramethyl-tetralin (88299) (AETT), were reviewed. The alterations included a ceroid like pigmentation, demyelination affecting the central and peripheral nervous systems, and behavioral changes associated with heightened irritability and limb weakness. A dose of 50mg/kg AETT per day induced a characteristic intermittent abnormal arching of the back concomitant with hopping ambulation, ataxia, and splaying. The behavioral changes were associated with a progressive blue discoloration of the skin, the eyes, the visceral organs, and nerve tracts. Structural changes affecting the nervous system included a progressive and irreversible lipopigmentation of neuronal perikarya, Schwann cells, astrocytes, and oligodendrocytes. Histochemical analysis of the neuronal lipopigment granules revealed similarities to the fluorescent and ultrastructural features of the ceroid lipopigment associated with human ceroid lipofuscinosis. Pigmentation was followed by demyelination characterized by splitting of the myelin sheath, edematous vacuolation, and myelin bubbling. The authors conclude that AETT may be useful for study of the etiology and pathogenesis of both neuronal lipopigment disorders and those myelinopathies associated with segmental bubbling of the myelin sheath.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Cosmetics-industry; Neuropathology; Nerve-tissue; Peripheral-nervous-system; Microscopic-analysis; Laboratory-animals
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
Neurotoxic Disorders; Neurotoxic-effects
Yeshiva University, New York, New York