Platelet adherence to cultured endothelial cells is increased by cotton bract tannin.
Helgeson-SC; Rohrbach-MS; Johnson-CM
Cotton dust: proceedings of the Twelfth Cotton Dust Research Conference, beltwide cotton research conferences, January 6-7, 1988, New Orleans, Louisiana. Wakelyn PJ, Jacobs RR, Rylander R, Burrell R, Peterson Y, eds. Memphis, TN: The National Cotton Council of America, 1988 Jan; :117-120
The possibility that tannin (1401554) mediated platelet adherence to endothelial cells may contribute to the lung injury seen in byssinosis was investigated. Treatment with cotton bract tannin caused a significant, dose dependent increase of platelet adherence to both porcine thoracic aorta and pulmonary artery endothelial cells. The binding of platelets to both types of endothelial cell was localized to the intercellular junctions, suggesting a connection between tannin cytotoxicity and tannin induced platelet adherence. The exposure of the platelets to tannin treated endothelial cells did not significantly change the platelet release of 5-hydroxytryptamine (serotonin). The treatment of endothelial cells and platelets with 1 millimolar aspirin had minimal effect on subsequent tannin mediated platelet adherence. The introduction of an inhibitor of thromboxane-A2 binding was unable to significantly change any tannin mediated platelet adherence.
NIOSH-Grant; Pulmonary-system-disorders; Animal-studies; In-vitro-studies; Pulmonary-function; Cotton-dust; Lung-cells; Blood-cells; Alveolar-cells;
Internal Medicine Mayo Foundation 200 First Street S W Rochester, MN 55905
Wakelyn-PJ; Jacobs-RR; Rylander-R; Burrell-R; Peterson-Y
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Cotton dust: proceedings of the Twelfth Cotton Dust Research Conference, beltwide cotton research conferences, January 6-7, 1988, New Orleans, Louisiana
Mayo Foundation, Rochester, Minnesota