Photosensitivity caused by pesticides.
Horiuchi N; Ando Y
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah. International Association of Agricultural Medicine, 1978 Sep; :279-284
A study of the incidence of pesticide induced photosensitivity in a farming population was conducted. The cohort consisted of 88 patients with pesticide dermatitis treated at Saku Central Hospital, Japan, over a 3 year period. Fifteen patients (11 males) had solar dermatitis. Fifty two subjects were evaluated in photopatch tests with gramoxone (1910425), trifluralin (1582098), TOK (1836755) (NIP), daconil (1897456), Des (62737) (DDVP), sumithion (122145), tedion (116290), mitran (80331), CNP, or kelthane (115322). The ultraviolet absorption spectra of the compounds were measured. The minimal erythema doses (MEDs) were determined in 56 patients. The data were compared with previously published data on the erythemic response of patients with solar dermatitis. The amount of ultraviolet radiation reaching the surface on sunny days was measured monthly for 1 year. Approximately 55.4 percent of the patients had MEDs of less than 3 minutes. Comparison with previously published data showed that 66.1 percent of other solar dermatitis patients and 88.7 percent of the comparison subjects had MEDs of less than 3 minutes. The photopositivity rates were: gramoxone 21.2 percent, trifluralin 7.7 percent, NIP 5.8 percent, daconil 19.2 percent, DDVP 15.4 percent, sumithion 5.8 percent, and tedion and mitran 3.8 percent. CNP and kelthane gave negative responses. The intensity of incident ultraviolet radiation was greatest in March and April. The absorption spectra suggested that NIP may be phototoxic and DDVP and tedion could be photoallergenic. Sumithion and trifluralin could induce phototoxicity and photoallergy. The authors conclude that 17 percent of the patients with pesticide dermatitis show phototoxic lesions. The maximum solar ultraviolet radiation reaches the ground in the spring. The MEDs of patients with pesticide dermatitis are greater than in healthy individuals. Gramoxone, daconil, DDVP, trifluralin, NIP, and sumithion are photosensitizing agents.
NIOSH-Grant; Grants-other; Skin-disorders; Epidemiology; Agricultural-workers; Skin-exposure; Agricultural-chemicals; Ultraviolet-radiation; Occupational-exposure; Dose-response; Patch-tests
Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
1910-42-5; 1582-09-8; 1836-75-5; 1897-45-6; 62-73-7; 122-14-5; 116-29-0; 80-33-1; 115-32-2
Other Occupational Concerns; Grants-other
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah
University of Iowa, Iowa City, Iowa