Male fertility effects of glycol ethers - a quantitative analysis.
Hattis-D; Welch-LS; Schrader-SM
Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts, Report No. CTPID-88-3, 1988 Dec; :1-117
The effects on male fertility from reductions of sperm counts as a result of exposure to the glycol ethers 2-ethoxyethanol (110805) (EE) and 2-methoxyethanol (109864) (ME) were investigated, using data from two recent studies. The first was a study of Oregon foundry workers, and the second involved a group of shipyard painters. The average EE exposures for the Oregon foundry workers were in the range of 9 to 14 parts per million (ppm). A suggestive decline in sperm count was noted for the exposed group as a whole, but the difference was not statistically significant. The painter group was exposed to considerably lower levels of EE and in addition had appreciable exposure to ME. The sperm counts of the exposed painters were lower, but, again, not significantly so. These studies reinforce each other, suggesting that these exposures caused a reduction in sperm count. Based on the sperm count changes, the increase in the numbers of couples expected to experience a significant delay in achieving pregnancy and to seek medical treatment and the monthly probability of achieving pregnancy with the female partner drawn from a particular population were predicted. Problems with different terminology in studies such as these were briefly discussed and suggestions were offered for further research.
NIOSH-Contract; Reproductive-system-disorders; Fetus; Solvents; Alcohols; Shipyard-workers; Foundries; Metabolic-study; Air-quality-monitoring; Urinalysis
NTIS Accession No.
Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts, Report No. CTPID-88-3, 117 pages, 111 references