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Contact dermatitis from B. subtitliss-derived protease enzymes.
Smith-DJ; Mathias-CG; Greenwald-DI
Contact Dermatitis 1989 Jan; 20(1):58-59
A case of contact dermatitis from exposure to Bacillus-subtilis derived proteolytic enzymes was described. The patient was a 35 year old male mixer for a large bakery who presented with symptoms of palmar dermatitis. The job required the manual addition of sodium-sulfite, phospholux, gelatin, and tablets of concentrated proteolytic enzymes from Bacillus-subtilis to the dough. The dermatitis resolved during a 5 month layoff but recurred upon return to work. Intermittent dermatitis occurred over a 9 month period with severe symptoms after 3 consecutive weeks as a mixer. Biopsy indicated acute spongiotic dermatitis. Acute treatment involved oral prednisone administration and sick leave for 3 weeks. The dermatitis resolved over a period of 6 months following transfer out of the mixing area. Patch tests were negative for Bacillus-subtilis protease, sodium-sulfite, phospholux, and baking gelatin. The authors conclude that the mixer suffered from contact dermatitis attributable to the irritant skin effects of proteolytic enzymes derived from Bacillus-subtilis.
NIOSH-Author; Contact-dermatitis; Food-processing-workers; Skin-irritants; Enzyme-activity; Biological-material; Food-additives; Occupational-exposure
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Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division