Heart disease mortality among bridge and tunnel officers exposed to carbon monoxide.
Stern-FB; Halperin-WE; Hornung-RW; Ringenburg-VL; McCammon-CS
Am J Epidemiol 1988 Dec; 128(6):1276-1288
Heart disease mortality among bridge and tunnel officers occupationally exposed to carbon-monoxide (630080) was examined in a retrospective study of 5,529 subjects employed between 1952 and 1981 at any one of nine New York City water crossings. Among former tunnel officers, there were 61 deaths from arteriosclerotic heart disease, a 35 percent excess risk compared with the New York City population. Examination of the risk of mortality from arteriosclerotic heart disease among tunnel officers in comparison to the less exposed bridge officers using a proportional hazards model indicated no observable association of arteriosclerotic heart disease with length of exposure; there was, however, significant interaction of exposure with age. The elevated risk of arteriosclerotic heart disease among tunnel officers declined after cessation of exposure, with much of the increased risk dissipating within as a little as 5 years. The authors conclude that exposure to carbon-monoxide may be a major factor in arteriosclerotic heart disease mortality; the parallel findings of this study and studies showing the relation of cigarette smoking to cardiovascular mortality suggest that carbon-monoxide may play an important role in the pathophysiology of cardiovascular mortality associated with cigarette smoking.
NIOSH-Author; Epidemiology; Mortality-rates; Risk-factors; Cardiovascular-disease; Cardiovascular-system-disease; Toxic-gases; Tunnel-workers; Environmental-exposure; Long-term-exposure; Cigarette-smoking
American Journal of Epidemiology