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Special occupational hazard review for DDT.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-200, 1978 Sep; :1-214
This Hazard Review examined problems associated with the use and manufacture of DDT (50293). The use of DDT has been restricted in the United States to specific applications by the Department of Agriculture and the Public Health Department, and for controlling body lice. In other countries, DDT was still used widely in agriculture and for vector control. Studies indicated that the estimated oral toxicity for humans was 250mg/kg. Animal studies suggested that chronic effects may occur in humans exposed for long periods of time, possibly even the production of cancer. DDT has produced an increased incidence of tumors in mice, mostly involving the liver, but also involving the lungs and lymphatic system. Studies with mice showed increased tumor incidence at dietary level as low as 2 to 10 parts per million. NIOSH recommends that DDT be controlled and handled in the workplace as a suspected carcinogen. Exposure should be kept to the minimum. Airborne levels of DDT should not exceed 0.5mg/m3. Workers should avoid skin contact as the pesticide can be absorbed through the skin. This absorption is enhanced in the presence of organic solvents.
NIOSH-Criteria-Document; Organo-chlorine-compounds; Pesticides; Agricultural-chemicals; Chlorinated-hydrocarbon-pesticides; Toxic-effects; Carcinogens; Occupational-exposure
Numbered Publication; Criteria Document
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-200
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division