Special occupational hazard review for aldrin/dieldrin.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-201, 1978 Sep; :1-175
This review analyzed and documented, from a health standpoint, the problems associated with the use of aldrin (309002) and dieldrin (60571). In the United States, the production of these pesticides had been banned, although certain restricted uses were allowed. Studies have indicated that the estimated acute oral toxicity for humans is 65mg/kg. Animal studies indicated that both had considerable potential for carcinogenic effects in humans, having produced tumors in mice. Dieldrin caused significant increases in lung and liver tumors at dietary doses as low as 0.1 and 1 part per million, respectively. NIOSH recommends these two chemicals be handled in industry and the workplace as suspected occupational carcinogens, even though direct support evidence among humans is missing. Airborne concentrations of either chemical should not exceed 0.15mg/m3. Skin contact should be avoided as they can both be absorbed through the skin. When dissolved in organic solvents, this percutaneous absorption is greatly increased. Other aspects discussed in this review include the metabolism and pharmacokinetics, mode of action of general toxicity in animal studies, effects on central nervous system and peripheral motor effects among animals, reproductive effects in animals, and effects on humans in relation to clinical studies, case reports and epidemiological surveys.
NIOSH-Criteria-Document; Agricultural-chemicals; Agricultural-workers; Toxic-effects; Organo-chlorine-compounds; Teratogens; Carcinogens; Laboratory-animals; Chlorinated-hydrocarbon-pesticides
Numbered Publication; Criteria Document
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-201
National Institute for Occupational Safety and Health