Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-212, 1978 Sep; :1-163
NIOSH recommends in this document that worker exposure to nitriles shall not exceed the following specified limits: acetone- cyanohydrin (75865), 4mg/m3; glycolonitrile (107164), 5mg/m3; tetramethylsuccinonitrile (3333526), 6mg/m3; malononitrile (109773), 8mg/m3; propionitrile (107120), 14mg/m3; adiponitrile (111693), 18mg/m3; succinonitrile (110612), 20mg/m3; n-butyronitrile (109740), 22mg/m3; isobutyronitrile (78820), 22mg/m3; and acetonitrile (75058), 34mg/m3. Recommendations were included for environmental sampling and analysis of workplace air, medical surveillance of employees, labeling and posting, use of personal protective equipment and clothing, training of employees regarding hazardous exposures, work practices and control procedures, sanitation, monitoring and recordkeeping requirements. Effects of selected nitriles on humans include bronchial tightness, gastric distress, respiratory distress, hypotension, conjunctivitis, chest pain, skin discoloration, tachypnea, dizziness, vomiting, convulsions, coma, cyanosis, retching, thyroid reaction, duodenal ulcers, eye irritation, and muscle spasms. No reports were identified which discuss possible carcinogenic, mutagenic, or teratogenic effects of these nitriles, except adiponitrile which was tested for mutagenicity and found to lack this quality.