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Criteria for a recommended standard... occupational exposure to ethylene dichloride (1,2-dichloroethane).
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-139, 1976 Mar; :1-165
NIOSH recommends in this document that worker exposure to ethylene- dichloride (107062) be controlled so that no worker is exposed in excess of 5 parts per million (ppm) determined as a time weighted average for up to a 10 hour workday, 40 hour workweek, or to peak concentrations above 15ppm as determined by a 15 minute sample. Nursing mothers should not work with ethylene-dichloride. Medical provisions include the offering of comprehensive preplacement and annual medical examinations, proper medical management for exposed workers, and the keeping of medical records. Labeling requirements are defined. Personal protective equipment and clothing for workers includes respiratory protection, gloves, boots, overshoes, and bib type aprons, and eye protection. Employees shall be informed of the hazards from ethylene-dichloride exposure. Good work practices shall be maintained and emergency procedures and confined space entry procedures fully outlined. Documented effects on humans from exposure included death as a result of ingestion, preceded by dizziness, nausea, vomiting, and unconsciousness. Autopsies revealed hyperemia and hemorrhagic lesions of most organs. Inhalation of vapors has also resulted in death with similar pathological findings. Repeated and chronic occupational exposures have resulted in anorexia, nausea, vomiting, epigastric pain, irritation of the mucous membranes, and liver and kidney dysfunction. A delay in the onset of symptoms following inhalation exposures may signify the metabolism of the parent compound to more toxic metabolites. Ethylene-dichloride has been shown to be weakly mutagenic.
NIOSH-Criteria-Document; Chemical-manufacturing-industry; Agricultural-chemicals; Insecticides; Chlorinated-ethylenes; Chlorinated-hydrocarbons; Toxic-effects; Mutagens
Numbered Publication; Criteria Document
NTIS Accession No.
DHEW (NIOSH) Publication No. 76-139; Contract-099-73-0020
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division