Cytogenetic study of a rural population.
Fujita K; Fujita HM
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah. International Association of Agricultural Medicine, 1978 Sep; :310-311
A cytogenetic survey of a rural farming population was conducted. The study group consisted of an unspecified number of persons over the age of 20 years living in Yachiho Village, Nagano Prefecture, Japan, who were engaged in cultivating rice, vegetables, apples, and flowers. An unspecified number of nonfarming village residents served as comparisons. Peripheral venous blood samples were collected and the leukocytes were isolated. After stimulation with phytohemagglutinin and colchicine the cells were examined for chromosome aberrations. Chromatid and chromosome breaks were the most frequently seen aberration in both farming and nonfarming subjects. The frequency of chromatid and chromosome breaks was higher in the farming than in the nonfarming subjects. The frequency of chromatid and chromosome breaks in the farmers increased strongly with increasing age. The authors conclude that a high chromosomal breakage rate has been found in farmers living in Yachiho Village. Although the farmers use large quantities of pesticides, it cannot be concluded definitely that the high breakage rate is caused by exposure to pesticides. Heavy pesticide use, however, could be associated with an elevated frequency of chromosome breaks.
NIOSH-Grant; Grants-other; Agricultural-workers; Blood-cells; Chromosome-disorders; Age-factors; Agricultural-chemicals; Occupational-health; Risk-analysis
Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
Other Occupational Concerns; Grants-other
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah
University of Iowa, Iowa City, Iowa