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Delayed neurotoxicity of organophosphate insecticides.
Ueda K; Iyatomi A; Kawai M
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah. International Association of Agricultural Medicine, 1978 Sep; :276-278
The delayed neurotoxicity of organophosphate insecticides was studied in hens. White-Leghorn-hens were administered single oral doses of leptophos (21609905), a derivative of O-(2,5- dichlorophenyl)phenylphosphonothioate (25DCP), a derivative of O- (2,4,5-trichlorophenyl)phenylphosphonothioate (245TCP), a derivative of O-(2,4-dichlorophenyl)phenylphosphonothioate (24DCP), EPN (2104645), methyl-EPN, or tri-ortho-cresylphosphate (78308) (TOCP). The doses ranged from 200 milligrams per kilogram (mg/kg) up to 1000mg/kg. Other hens were given five doses of 50mg/kg EPN each day every 3 days for 2 weeks. The birds were observed for signs of delayed neurotoxicity for up to 27 days after dosing. Development of leg paralysis was taken as evidence of delayed neurotoxicity. Leptophos at 200mg/kg induced delayed neurotoxicity. 25DCP and 245TCP at 100mg/kg induced delayed neurotoxicity in 80 percent of the hens after 2 to 3 weeks. 24DCP at 1000mg/kg induced delayed neurotoxicity in 50 percent of the birds. TOCP at 200mg/kg induced delayed neurotoxicity in 50 percent of the hens. Single doses of EPN and methyl-EPN did not produce any evidence of delayed neurotoxicity. However, when given in divided doses, EPN induced delayed neurotoxicity in all birds 1 week after the fifth dose. The authors conclude that organophosphate insecticides having the structural entity O-methyl-O-(chlorinated phenyl)phenylphosphonothioate appear to cause delayed neurotoxicity in hens.
NIOSH-Grant; Grants-other; Organo-phosphorus-compounds; Molecular-structure; In-vivo-studies; Animal-studies; Dose-response; Neurotoxic-effects; Feeding-study; Agricultural-chemicals; Acute-exposure; Clinical-symptoms
Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
21609-90-5; 2104-64-5; 78-30-8
Other Occupational Concerns; Grants-other
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah
University of Iowa, Iowa City, Iowa
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division