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Relation between malignant tumors of the urogenital tract and endemic nephropathy.
Milosevic M; Miletic N; Milosevic R
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah. International Association of Agricultural Medicine, 1978 Sep; :112-117
A study of the association between malignant tumors of the urogenital tract and progressive kidney failure (endemic nephropathy) was conducted. The study group consisted of 7090 persons over the age of 15, 3952 females, living in the Cuprija area, Yugoslavia, an area which has a high incidence of endemic nephropathy. The subjects were screened by interview and clinical testing for albumin which was used as a marker for endemic nephropathy. All subjects with positive anamnestic data and positive tests for urinary albumin were given physical examinations that included urine and blood chemistry studies. The incidence of urogenital tumors was determined from the anamnestic data and a tumor registry. A total of 491 subjects (6.9 percent) had endemic nephropathy. The incidence was higher in females than males, 7.6 versus 6.0 percent, respectively. Approximately 19.3 percent of the subjects with endemic nephropathy reported having a family member with renal disease. Sixty three subjects reported having a family member who had a renal tumor. The frequency of urogenital tumors was nine times higher in subjects with endemic nephropathy than in those with no kidney disease. When stratified by age, endemic nephropathy began appearing in subjects when they reached their 20s and urogenital tumors began appearing in subjects in the fourth decade of life. The authors conclude that the incidence of malignant urogenital tumors is nine times higher in persons with endemic nephropathy than in those without kidney disease.
NIOSH-Grant; Grants-other; Kidney-disorders; Kidney-tumors; Epidemiology; Age-factors; Sex-factors; Health-surveys; Medical-examinations; Disease-incidence
Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
Other Occupational Concerns; Grants-other
Proceedings of the VII International Congress of Rural Medicine, September 17-21, Salt Lake City, Utah
University of Iowa, Iowa City, Iowa
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division