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Screening of Priority Chemicals for Reproductive Hazards. Monoethanolamine (CAS No. 141-43-5), Diethanolamine (CAS No. 111-42- 2), Triethanolamine (CAS No. 102-71-6).
Environmental Health Research and Testing, Inc., Cincinnati, Ohio 1987 Apr:61 pages
Monoethanolamine (141435), diethanolamine (111422), and triethanolamine (102716) were screened for their ability to cause adverse reproductive effects using a postnatal mouse screening test. Phase one and two of the tests involved the determination of the median lethal dose for these chemicals and the third phase involved the reproductive effects study. In the first phase doses were administered by gavage on 5 consecutive days. In the second and third phases the doses were given on gestation days six through 15. Monoethanolamine, administered at 850mg/kg/day, was toxic to pregnant animals causing a 16 percent mortality. Monoethanolamine reduce the number of viable litters but did not affect litter size, the percent survival of the pups, the birth weight of the pups or the weight gained by the pups. Diethanolamine, administered at 1125mg/kg/day, caused no change in maternal mortality, number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups. Triethanolamine, administered at 1125mg/kg/day, did not affect maternal mortality, the number of viable litters, litter size, percent survival of the pups, birth weight of the pups or weight gained by the pups.
NIOSH-Contract; Contract-200-84-2735; Embryotoxicity; Fetus; Teratogenesis; Reproductive-effects; Ethanolamines; Laboratory-animals; Lubricants; Reproductive-hazards;
141-43-5; 111-42-2; 102-71-6;
NTIS Accession No.
Environmental Health Research and Testing, Inc., Cincinnati, Ohio
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division