Benzethonium-chloride (121540), 3-ethoxy-1-propanol (111353), and acetone (67641) were screened for their ability to cause adverse reproductive effects as evidenced through the postnatal mouse screening test. Phases one and two were intended to identify the appropriate dose levels, while phase three was intended to determine reproductive effects. Treatment was administered to female CD-1- mice by gavage on 5 consecutive days during phase one and on gestation days six through 15 in phases two and three. Benzethonium- chloride caused excessive maternal mortality and a decrease in the reproductive index, in the percent survival of the pups and in the birth weight of the pups but had no effect on litter size or weight gain. 3-Ethoxy-1-propanol caused a high maternal mortality and a decrease in the reproductive index, in the percent survival of the pups and in the birth weight of the pups. No effect was observed on litter size or weight gain. Acetone did not cause an increase in maternal mortality but did increase the weight gain by the pups and decreased the reproductive index, the percent survival of the pups and the birth weight of the pups. No effect was noted on litter size.
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