Screening of Priority Chemicals for Reproductive Hazards. Triorthocresyl Phosphate (CAS No.: 78-30-8), 4,4'-Thiobis (6-t- Butyl-m-cresol) (CAS No.: 96-69-5), 13-cis-Retinoic Acid (CAS No.: 4759-48-2).
Environmental Health Research and Testing, Inc., Cincinnati, Ohio 1987 Apr:64 pages
Triorthocresyl-phosphate (78308), 4,4'-thiobis(6-t-butyl-m-cresol) (96695), and 13-cis-retinoic-acid (4759482) were screened for their potential to cause adverse reproductive effects using a postnatal mouse screening test. In the first two phases of the study experiments were designed to determine the appropriate dose levels for the different compounds. In the third phase the reproductive effects were studied. Female CD-1-mice were dosed by gavage on 5 consecutive days for phase one and on gestation days six through 15 for the second and third phases of the study. The predicted median lethal dose for triorthocresyl-phosphate was 515mg/kg/day and for 4,4'-thiobis it was 485mg/kg/day. The 13-cis-retinoic-acid (4759482) was administered at 85mg/kg/day, due to the limited amount of chemical available. All animals received a constant volume of 10 milliliters/kilogram/day. Triorthocresyl-phosphate cause an increased maternal mortality and a decreased number of viable litters but had no effect on litter size or birth weight gain. 4,4'- Thiobis(6-t-butyl-m-cresol) caused increases in maternal mortality and a decreased percent of pup survival while not affecting the number of viable litters, the litter size, birth weight or weight gain of the pups. 13-cis-Retinoic-acid had no effect on maternal mortality, the number of viable litters, litter size, or pup birth weight.
NIOSH-Contract; Contract-200-84-2735; Laboratory-animals; Reproductive-effects; Phosphates; Embryotoxicity; Fetus; Teratogenesis; Toxic-effects; Reproductive-hazards;
78-30-8; 96-69-5; 4759-48-2; 4759-48-2;
NTIS Accession No.
Environmental Health Research and Testing, Inc., Cincinnati, Ohio