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Membrane models for skin penetration studies.

Houk J; Guy RH

Departments of Pharmaceutical Chemistry and Pharmacy, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 1987 Dec; :1-67

00182754

The results of research efforts into membrane models for skin penetration were reviewed. Eggshell membrane has been suggested as a model for human skin primarily because it consists of keratin. This membrane system was shown to contain both hydrated proteinaceous and lipoidal phases known to be present in stratum corneum, and was deemed potentially promising for skin transport studies. The use of two or more different membranes combined into a composite or laminate was investigated. A different approach was the use of a membrane composed of synthetic zeolites incorporated into a polystyrene matrix, but their future for skin transport studies did not appear promising. Experiments designed to assess how the skin permeability of phenol was changed by thermal injury indicated that solution phenomena were not able to provide a mechanism for the enhanced phenol permeability found with increased concentrations of phenol. The use of simple organic liquids as models for biological membranes has been suggested since the turn of this century. Early studies in this field involved evaluation of the kinetics of drug transfer through bulk organic phases. The rotating diffusion cell (RDC) was a relatively new method for characterizing transport phenomena which has been used in model skin penetration studies. Developments which have occurred during the last few years in this field were also reviewed.

NIOSH-Grant; Dermatitis; Skin-exposure; Skin-absorption; In-vitro-studies

Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143

19871201

Final Grant Report

93049

Grant

1988

PB89-131239

A05

Grant-Number-K01-OH-00017

OEP

Dermatitis

Departments of Pharmaceutical Chemistry and Pharmacy, Schools of Pharmacy and Medicine, University of California, San Francisco, California

CA

University of California San Francisco, San Francisco, California