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Cutaneous responses to topical methyl nicotinate in black, oriental and caucasian subjects.
Gean CJ; Tur E; Maibach HI; Guy RH
Departments of Pharmacy, Pharmaceutical Chemistry and Dermatology, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 1987 Dec; :1-23
Assessments were made of cutaneous responses to topically applied methyl-nicotinate (93607) (MN) on black, oriental, and Caucasian subjects to determine if racial differences had any part to play in percutaneous absorption and microcirculatory sensitivity. Both visual and laser Doppler velocimetry evaluations were made of the MN induced vasodilatation. Specific assessment was made of the diameter of the maximum visually perceptible erythematous area, the area under the erythematous diameter versus time curve, the maximum laser Doppler velocimetry response, and the area under the laser Doppler velocimetry response versus time curve. For all subjects each of the measures above mentioned was dependent on the dose of MN applied with the exception of the maximum laser Doppler velocimetry response. The authors conclude that although some racial differences did appear to exist in response to topical MN, the perception of these distinctions may depend on the method of measurement.
NIOSH-Grant; Dermatitis; Skin-exposure; Skin-absorption; Racial-factors
Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
Final Grant Report
NTIS Accession No.
Departments of Pharmacy, Pharmaceutical Chemistry and Dermatology, Schools of Pharmacy and Medicine, University of California, San Francisco, California
University of California San Francisco, San Francisco, California
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