Principles of skin permeability relevant to chemical exposure.
Departments of Pharmacy and Pharmaceutical Chemistry, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 1987 Dec; :1-54
Biological and physicochemical parameters which determine the rate and extent of chemical penetration across the human skin were identified. Such exposures may represent a significant occupational hazard. Anatomical features of the skin that control the barrier to absorption were reviewed. The interaction of the physiological parameters with the physicochemical properties of the dermally contacting chemical were discussed to determine the kinetics and degree of penetration which will be accomplished. The relationship between chemical structure and activity and penetration of the skin was reviewed for n-alkanols, phenols, phenylboronic acids, steroids, nicotinic-acid esters, alkanoic acids, polynuclear aromatics, and nonsteroidal antiinflammatory drugs. Using skin absorption data for the forearm alone it is possible to calculate relative body exposures; to model this process of skin absorption effectively is a complex undertaking. The simplest treatment involves the use of Fick's laws of diffusion and an estimation of total body burden following a dermal exposure. Another approach based on the physicochemical properties of the penetrant was also discussed.
NIOSH-Grant; Dermatitis; Skin-exposure; Models; Skin-sensitivity
Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
Final Grant Report
NTIS Accession No.
Departments of Pharmacy and Pharmaceutical Chemistry, Schools of Pharmacy and Medicine, University of California, San Francisco, California
University of California San Francisco, San Francisco, California