Occupational and environmental factors in congenital biliary atresia.
Department of Environmental Health Sciences, The John Hopkins University, Baltimore, Maryland 1987 Nov; :1-9
An etiologic case/control study with nationwide participants was designed to determine occupational and environmental factors at work in the development of congenital biliary atresia (BA). The total number of referred cases was 669 and included surviving, deceased, and successfully transplanted cases. Preliminary findings for selected variables among the families of 333 subjects suggested that case families had significantly lower estimated median incomes. Subsequent analyses should indicate whether the case parents had increased frequencies of lower paying, unskilled/laborer or blue collar jobs. The shift of income level to the lower end of the spectrum may suggest that case parents have on the job exposures to reproductive toxins or fetotoxic substances. The data suggested a higher percentage of abortion or stillbirths occurring prior to the conception of the BA case than were present in comparison families. This finding may suggest possible exposures to reproductive toxins causing both recognized and unrecognized spontaneous abortions for case mothers. Maternal smoking during pregnancy did not seem related to BA. The data were being examined to determine if association with farm work or military work where herbicide spraying may have occurred was linked with reproductive failure, or if association with welding operations could be linked to reproductive system malfunction.
NIOSH-Grant; Reproductive-system-disorders; Genotoxic-effects; Agricultural-workers; Farmers; Agricultural-chemicals; Military-personnel; Welders; Welding-industry
Environmental Health Sciences Johns Hopkins Sch of Hygiene 615 North Wolfe Street Baltimore, MD 21205
Final Grant Report
NTIS Accession No.
Department of Environmental Health Sciences, The John Hopkins University, Baltimore, Maryland
Johns Hopkins University, Baltimore, Maryland