Coal liquids: skin toxicity and mutagenicity studies.
Department of Dermatology, Case Western Reserve University, Cleveland, Ohio. 1985 Jan; :1-9
Summaries were included in this final progress report of the various research publications generated during the study of the effects of coal-tar (8007452) on xenobiotic metabolism in the skin. Specifically information was sought concerning the activity of aryl- hydrocarbon-hydroxylase (AHH). Neonatal rats were used to study the enzyme activity in epidermal, dermal, and other bodily tissues. Significant induction of AHH was noted in the tissues following topical application of benzo(a)pyrene (50328) (BP) or the Aroclor- 1254 (11097691) mixture. Skin enzymes demonstrated a greater activity than other extrahepatic tissues. Primary results of research into the induction of skin and liver AHH activities following topical application of coal tar were reported along with the results of coal tar application and subsequent induction of hepatic cytosolic glutathione-S-transferase and microsomal epoxide- hydrolase and aminopyrine N-demethylase activities. The drug metabolizing enzyme activity and the hemeprotein cytochrome-P-450 and epoxide-hydrolase activities were compared in skin, epidermal, and dermal tissues following coal tar administration and the enzyme activities in the liver, lung, kidney, and intestine were also examined.
NIOSH-Grant; Dermatitis; Liver-microsomal-enzymes; Chlorinated-hydrocarbons; Aromatic-hydrocarbons; Coal-tar-pitch; Coal-workers; Coal-products; Skin-exposure; Laboratory-animals
Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
8007-45-2; 50-32-8; 11097-69-1
Final Grant Report
NTIS Accession No.
Department of Dermatology, Case Western Reserve University, Cleveland, Ohio
Case Western Reserve University, Cleveland, Ohio