NIOSHTIC-2 Publications Search

In depth biochemical, pharmacological and metabolic studies on trihalomethanes in water.

Authors
Bull RJ; Robinson M; Brown TJ; Mink FL; Lingg RD; Whitmire C
Source
Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland. Kraybill HF, Blackwood IC, Freas NB, eds. Washington, DC: National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health, 1980 May; :412-445
NIOSHTIC No.
00182251
Abstract
The risks associated with the occurrence of chloroform (67663) and other trihalomethanes in drinking water were examined by in depth biochemical, pharmacological, and metabolic studies. Osborne-Mendel- rats and B6C3F1-mice were exposed to doses of chloroform in drinking water ranging from 0 to 2700 parts per million; animals were sacrificed at 30, 60, or 90 days for chemical analyses (serum glutamate-oxalacetate-transaminase, lactic-dehydrogenase, blood urea nitrogen, serum glutamate-pyruvate-transaminase, and serum triglycerides). Tumors and lesions were examined microscopically. For the metabolic studies, animals were dosed with radiolabeled chloroform by intragastric intubation; feces, urine, and expired air were sampled at various time intervals, and radioactivity in selected tissues and organs determined. Results indicated a decrease in the level of enzymes classically found in serum following acute liver injury. Mice appeared much more sensitive than rats to the development of fatty liver. Histopathological evidence of fatty infiltration of the liver was observed in the mice at all sacrifice periods of the subchronic study. The authors conclude that the data supports the contention that the ability of chloroform to produce liver tumors is not separable from its ability to damage the liver.
Keywords
Laboratory-animals; Chloromethanes; Biochemical-analysis; Drinking-water; Chlorinated-hydrocarbons; Metabolic-study; Liver-damage; Liver-enzymes
CAS No.
67-66-3
Publication Date
19800101
Document Type
Conference/Symposia Proceedings
Editors
Kraybill HF; Blackwood IC; Freas NB
Fiscal Year
1980
Source Name
Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland
State
MD; DC
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division