Zinc effects on nickel dermatitis in the guinea pig.
Warner-RD; Dorn-CR; Blakeslee-JR; Gerken-DF; Gordon-JC; Angrick-EJ
Contact Dermatitis 1988 Aug; 19(2):98-108
The possibility that zinc supplementation, with zinc-sulfate in drinking water, during nickel (7440020) (Ni) sensitization and challenge effects nickel induced allergic contact dermatitis in female Hartley-guinea-pigs was investigated. A comparison was made of in-vitro lymphocyte transformation test responses with in-vivo intradermal hypersensitivity test responses in Ni exposed and nonexposed guinea-pigs. A significant affect on lymphocyte response, as measured in the lymphocyte transformation test, was noted when animals received zinc supplementation in the drinking water from 4 weeks prior to nickel exposures through the period of challenge. Oral intake of zinc-sulfate at 250 micrograms/milliliter (microg/ml) and 500microg/ml significantly lowered stimulation indices (SIs) from control levels. No significant correlation was noted between intradermal test responses and the SI values of individual guinea-pigs exposed to nickel-sulfate. No statistically different concentrations of zinc were found in the skin or whole blood for zinc supplemented groups or between nickel sensitive and nonsensitive animals within the groups.
NIOSH-Publication; NIOSH-Grant; Dermatitis; Laboratory-animals; Skin-exposure; Allergic-dermatitis; Allergic-reactions; Nickel-compounds; Contact-dermatitis
Veterinary Preventive Medicine Ohio State University 1900 Coffey Road Columbus, Ohio 43210
Ohio State University, Columbus, Ohio