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Experimental nitrous oxide exposure as a model system for evaluating neurobehavioral tests.
Mahoney FC; Moore PA; Baker EL; Letz R
Toxicology 1988 May; 49(2-3):449-457
The effect of nitrous-oxide (10024972) on neurobehavioral test performance was evaluated. Fifteen white males, 24 to 34 years old, were exposed to 0, 20, or 40 percent nitrous-oxide. They were then administered a computerized battery of neurobehavioral tests that evaluated continuous performance, hand/eye coordination, serial digit learning, symbol digit substitution, pattern recognition, pattern memory, choice reaction time, finger tapping, and mood. Performance was scored using 0 percent nitrous-oxide exposure as the baseline. The 20 percent exposure significantly impaired performance on the symbol digit and finger tapping tests. A marginally significant decrement in continuous performance test response latency was also seen. There was a significant effect on the confusion items in the Mood scales test. Nitrous-oxide at 40 percent impaired performance on all tests. The impairments were significant for all tests except the symbol digit learning task. Confusion on the Mood scales was significantly at this dose as well. The authors conclude that their findings agree with those of previous studies. Nitrous-oxide appears to be a useful standard for comparing the sensitivity of neurobehavioral tests. The computerized neurobehavioral test battery, particularly the Switching Attention task, is a valid technique for documenting functional status of the central nervous system.
NIOSH-Author; Humans; Laboratory-testing; Inhalation-studies; Nitrogen-oxides; Behavioral-testing; Mental-processes; Dose-response; Task-performance; Author Keywords: Computerized neurobehavioral testing; Nitrous oxide; validation
Richard Letz, Division of Environmental and Occupational Medicine, Box 1057, Mount Sinai School of Medicine, 10 East 103rd Street, New York, NY 10039, USA
Issue of Publication
MA; PA; GA; NY
Page last reviewed: January 29, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division