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Effects of 2.45-GHz microwave and 100-MHz radiofrequency radiation on liposome permeability at the phase transition temperature.

Authors
Liu-M; Cleary-SF
Source
Bioelectromagnetics 1988 Jul-Sep; 9(3):249-257
NIOSHTIC No.
00181398
Abstract
The effects of 100MHz continuous wave (CW) radiofrequency and 2.45 gigahertz (GHz) CW microwave radiation on liposome permeability and phase transition temperatures were investigated. Liposome vesicles loaded with tritiated cytosine-arabinofuranoside (ARA-C) were prepared by a reverse phase evaporation process from two purified, saturated phospholipids, dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG). The liposomes were then exposed for 30 minutes to 60 watt/kilogram (W/kg) CW 100 megahertz or 2.45GHz radiation in-vitro at temperatures from 37 to 43 degrees- C. Liposomes were exposed in HEPES buffer or in HEPES buffer supplemented with 44 percent by volume fetal calf serum (FCS). At temperatures between 39 and 40 degrees-C with the FCS present, characteristic phase transition responses were noted. Under these conditions the maximum percent release of tritium labeled ARA-C was increased by 20 percent relative to HEPES suspension. No detectable effect on liposome permeability or the location of the phase transition in the presence or absence of FCS was altered by either frequency of electromagnetic radiation.
Keywords
BIOEDI; NIOSH-Publication; NIOSH-Grant; Electromagnetic-fields; Electrical-fields; Magnetic-fields; Drug-therapy; Plasma-membrane; Chemotherapy; Nonionizing-radiation; Author Keywords: liposomes; dipalymitoylphosphatidylcholine; dipalymitoylphosphatidylglycerol; cytosine arabinofuranoside; radiofrequency; microwave radiation; fetal calf serum; phase transition temperature; membrane permeability
Contact
Li-Ming Liu, Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298
CODEN
BLCTDO
Publication Date
19880701
Document Type
Journal Article
Funding Amount
913524
Funding Type
Grant
Fiscal Year
1988
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002148
Issue of Publication
3
ISSN
0197-8462
Source Name
Bioelectromagnetics
State
VA
Performing Organization
Virginia Commonwealth University, Richmond, Virginia
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