Industrial dust interaction with respiratory mucosa.
Final Progress Report, 1982 Aug; :1-4
The interaction of selected organic and inorganic particulates with the respiratory epithelium was investigated. Organ cultures of trachea and monolayer cultures of epithelial cells derived from hamster trachea were used. The findings indicated that different types of dust generated different biological responses. The effects of various foreign materials adhering to dust particles were also explored with particular attention given to polycyclic hydrocarbons. An analysis of the uptake of polycyclic hydrocarbons on various types of asbestos (1332214) fibers and their release in conjunction with the proliferative effect on the respiratory epithelium was one such research project. The mechanism of interaction of particulates of different types with the membranes of cells was also studied using erythrocytes, cultured epithelial cells and liposomes with silica (7631869), talc (14807966), montmorillonite (1318930), bentonite (1302789), crocidolite (12001284) and chrysotile (12001295). Studies demonstrated the importance of the zeta potential in determining cytotoxicity. The role of naturally occurring substances such as mucins, surfactants, and proteins in altering the interaction of these particulates with the epithelial cells was discovered. The effects of viral infection on the response of the cavine respiratory epithelium to dust was also studied, and the results indicated that the interaction of carbon with respiratory epithelial cells was enhanced by the formation of multinuclear cells, induced by the virus.
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