NIOSHTIC-2 Publications Search
Protocol for Urine Monitoring Study of Workers Exposed to 4,4'- Methylene Dianiline.
NIOSH 1984 Aug:65 pages
Efforts were directed toward characterizing worker exposure to 4,4'- methylene-dianiline (101779) (4,4'-MDA) and evaluate the usefulness of collecting worker urine samples to assess exposure to 4,4'-MDA on the job. Industrial uses for 4,4'-MDA include as a curing agent for epoxy resin laminates, in industrial coatings for abrasion and corrosion resistance, in the formulation of high temperature polyester-imide wire coating enamels, in the production of chemically related derivatives, as a coreactant with polyurethanes, and in the production of electrical circuit boards. A review of pharmacokinetic studies was included, along with considerations of importance in biological monitoring, study site and worker selection factors, identification of biological variables, choosing a nonexposed comparison group, survey procedures, sampling methods, environmental sampling techniques, urinalysis methods and sample collection and processing, analytical procedures used for the air, wipe, and dermal samples, statistical methods used for the field data analysis, quality assurance procedures, safety of the investigators during the study, records management and data reporting.
NIOSH-Author; Carcinogens; Arylamines; Cancer-rates; Urine-chemistry; Curing-compounds; Epoxy-compounds; Sampling-methods;
NTIS Accession No.
Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 65 pages, 31 references
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division