Neoplastic effects of vinyl chloride in mouse lung - lower doses and short-term exposure.
Environmental Sciences Laboratory, Mount Sinai School of Medicine, City University of New York 1982 Nov; :1-20
Effects of exposure to 1 to 600 parts per million (ppm) vinyl- chloride (75014) over 4 week periods were investigated in 220 male CDI-Charles-River-mice. Exposure was for 6 hours/day, 5 days/week. At 12 weeks, 88.8 percent of those exposed to 600ppm and 66.6 percent of those exposed to 300ppm were found to have alveologenic tumors. In the 300ppm group these were all single tumors whereas the 600ppm group all had multiple tumors. A dose/response relationship was noted for tumor incidence as well as a dose related latency period. Dose and the recovery period after exposure seem to be the factors which determine the incidence of multiple alveologenic tumors. Larger tumors appeared to occur in the group receiving the higher dose levels and also in animals whose recovery period was longer. Spontaneous alveologenic tumors occurred in six animals. Histopathological examination revealed no evidence that tumor cells were derived from Clara cells of the terminal bronchioles. Neoplastic cells in both the tubulopapillary and adenomatous forms of the pulmonary tumors possessed all or some of the ultrastructural characteristics of type-II alveolar cells. Other tumors included hemangiosarcomas in the subcutaneous connective tissue of the ear (10ppm, 29 weeks after exposure) and the liver (600ppm, 65 weeks after exposure). The authors concluded that type-II alveolar cells are the most sensitive in mice to the neoplastic potential of vinyl-chloride exposure.
NIOSH-Grant; Laboratory-animals; Carcinogenesis; Tumorigenesis; Pulmonary-system-disorders; Lung-disorders; Liver-disorders; Liver-cancer; Lung-cancer;
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Environmental Sciences Laboratory, Mount Sinai School of Medicine, City University of New York
Mount Sinai School of Medicine, New York, New York