Asbestos-induced intrathoracic tissue reactions.
Gross-P; Harley-RA Jr.
Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania, 1988 Jan; :1-16
Research was conducted to test the trace metal hypothesis for the development of asbestos (1332214) related lung cancer while also documenting the occurrence of malignant intrathoracic tumors resulting following intrathoracic injections of different types of asbestos in the rats and hamsters. Rats and hamsters were injected with amosite (12172735), chrysotile (12001295) or crocidolite (12001284) prepared by one of five methods: hammer milled for 12 hours; ball milled for 2 hour, and heated at 900 to 1000 degrees-C; ball milled and treated with aqua-regia to remove trace metals; ball milled, treated with aqua-regia, and heated at 900 to 1000 degrees; or treated to avoid contact with metal. Animals injected with dusts that had been heated (dusts treated or untreated with aqua-regia) demonstrated a low tumor incidence, around 2 percent, whereas animals treated with dusts which had not been heated or treated demonstrated a 21 percent tumor rate in hamsters and 33 percent in mice. The 35 rat tumors were well differentiated and included 25 fibrosarcomas, four mesotheliomas, three rhabdomyosarcomas, two osteogenic sarcomas or fibrosarcomas with bone formation, and one fibroliposarcoma. Hamster tumors were undifferentiated sarcomas. The incidence of tumors in both species was least with chrysotile. The other two types of asbestos caused similar incidences of tumors in rats, but in hamsters amosite caused a higher incidence of tumors than crocidolite.
NIOSH-Grant; Laboratory-animals; Carcinogenesis; Tumorigenesis; Lung-disorders; Pulmonary-system-disorders; Asbestos-dust
None Industrial Hlth Fdn, Inc 5231 Centre Avenue Pittsburgh, PA 15232
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Final Grant Report
NTIS Accession No.
Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania
Industrial Health Foundation, Pittsburgh, Pennsylvania