Studies in zinc metabolism. IV. Interactions of Zn and Cd.
University of Cincinnati, Department of Environmental Health, Cincinnati, Ohio, 1981 Jan; :1-7
The effect of orally administered cadmium (7440439) on zinc (7440666) was studied in rats given cadmium at zinc to cadmium ratios of 1:5, 1:2, or 4:1. The effect of carbohydrate source on zinc and cadmium response was also studied. Growth was restricted only when the zinc intake was low in comparison to cadmium. Rats fed chow containing zinc and copper at ten times the optimal dietary levels were not affected by the cadmium dosing. Serum cholesterol and phospholipid levels were somewhat diminished with increased zinc. Cadmium concentrated mainly in the kidney, liver and pancreas with zinc showing a protective effect. The effect of cadmium on liver zinc content was greater when corn starch was fed. No appreciable increase of cadmium was noted in the testes or heart and very little localization in the lung or pancreas. Organ levels of copper and zinc were altered as a result of cadmium exposure. Effects were more pronounced at low levels of zinc nutrition. Cadmium concentrations were detectable in the hair, with the amount detected being related in zinc intake. Hair concentrations of zinc were considerably lower when corn starch was fed. Cadmium also increased the amount of zinc and copper in the hair. Copper content of hair was inversely related to zinc intake. These findings support earlier studies that low dietary levels of zinc and copper in the normal physiological range have important interactions and that low exposures to cadmium can only be studied in the context of dietary zinc and copper.
NIOSH-Grant; Laboratory-animals; Dietary-effects; Metabolic-study; Liver-damage; Kidney-damage; Body-burden; Tissue-distribution; Cadmium-compounds; Heavy-metals
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
Final Grant Report
NTIS Accession No.
University of Cincinnati, Department of Environmental Health, Cincinnati, Ohio
University of Cincinnati, Cincinnati, Ohio