Increase of Toxicity of Trace Anesthetics by UV Light.
Authors
Karis JH
Source
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, Terminal Progress Report :8 pages
Link
NIOSHTIC No.
00181253
Abstract
Efforts were made to determine whether trace amounts of halothane (151677) present in operating rooms and irradiated by ultraviolet (UV) light are harmful to operating room personal when chronically inhaled. The decomposition of halothane by UV light resulted in nine recognizable peaks using gas liquid chromatography. When halothane was irradiated in air or oxygen, photodecomposition was about ten times higher than when irradiated in nitrogen. Mice exposed to 3 percent UV irradiated halothane for 1 hour demonstrated an 80 percent mortality. Sleeping times increased five fold in mice exposed to 1.3 percent irradiated halothane for 90 minutes. Pentobarbital sleeping times were prolonged 1 day following exposure. An increase in serum transaminases was noted following exposure of mice to 1.3 percent irradiated halothane. Immediately following exposure to irradiated halothane, pulmonary toxicity was noted in mice. The lungs showed hemorrhagic lesions and the animals appeared dyspneic. Chronic exposures of male CD-1-mice for 7 hours/day, 5 days/week, for 30 days to 10, 100, or 1000 parts per million (ppm) UV irradiated or nonirradiated halothane were also carried out. There was no mortality in mice exposed to 10 or 100ppm, but there was a 20 percent mortality in mice exposed to 1000ppm irradiated halothane. Exposure to 1000ppm irradiated halothane resulted in a reduction in body weight. Enzyme levels were altered by exposure to irradiated halothane.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.