Mechanism of occupational leukoderma.
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-001556, 1986 Oct; :1-9
The binding and redox interactions of selected phenolic and catecholic compounds of widely varying potency were studied with model synthetic melanins, melanin-tyrosinase depigmenter (DP) complexes and with melanoproteins extracted from C-57-BL-6-black- mice. Using ferricyanide as an electron acceptor it was demonstrated that DP melanin binding can lead to alterations in electron transfer kinetics, and that the magnitude of such alterations may be roughly correlated with depigmenting potency. Attempts were made to induce hair depigmentation by local subcutaneous or intradermal injection of DPs into black-mice. A possible correlation was sought between DP potency and the behavior of one or more component interactions. The results of these studies will help in early detection and prediction of environmental depigmenters, attainment of a reliable regimen for effecting controlled depigmentation, effective use of the appropriate DP's as chemotherapeutic agents in malignant melanoma, and determination of mechanistic similarities and differences between occupational depigmentation and vitiligo.
NIOSH-Grant; Laboratory-animals; Pigmentation; Pigments; Pigmentation-disorders; Skin-disorders; Skin-exposure
Biochemistry Morehouse School of Medicine 830 Westrview Drive, SW Atlanta, Georgia 30314
Final Grant Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Morehouse School of Medicine, Atlanta, Georgia