Hair as a monitor of toxic chemicals exposure.
Jones-PF; Adams-S; Baumgartner-WA
Aerospace Corporation, Los Angeles, California, Aerospace Report No. ATR-0082(7950)-1, 1982 Aug; :1-9
The possibility of using hair analysis as a monitor of exposure to hydrazines and polychlorinated-biphenyls (1336363) (PCBs) was investigated. Two female Hartley-guinea-pigs injected with 0.6 milligrams (mg) of Aroclor-1254 (11097691) had analyzable concentrations of the PCB in their hair. Analysis was made using glass capillary gas chromatography with an electron capture detector. The levels ranged from 10 picograms/milligram (pg/mg) of Aroclor-1254 in washed hair to 100pg/mg in unwashed hair. Female Fischer-344-rats injected intraperitoneally with 60mg/kg unsymmetrical dimethyl-hydrazine (57147) (UDMH), 10mg/kg monomethyl- hydrazine (60344) (MMH) and/or 10mg/kg hydrazine (302012) did not have detectable amounts of these chemicals in their hair at 14, 30 or 42 days after injection. The hair samples did take up the hydrazines when suspended above solutions of the test compounds. The authors concluded that analyzing the PCB content of hair may be useful in providing a history of on the job PCB exposure.
NIOSH-Grant; Biological-monitoring; Environmental-contamination; Environmental-pollution; Insecticides; Pesticides; Chromatographic-analysis; Laboratory-animals
Analytical Sciences Aerospace Corporation 2350 E EL Segundo EL Segundo, Calif 90245
1336-36-3; 11097-69-1; 57-14-7; 60-34-4; 302-01-2
Final Grant Report
NTIS Accession No.
Aerospace Corporation, Los Angeles, California, Aerospace Report No. ATR-0082(7950)-1
Aerospace Corporation, EL Segundo, California