Respiratory tract irritants: mechanisms and tolerance (terminal progress report).
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, Terminal Progress Report, 1981 Nov; :1-6
An animal bioassay system was developed to evaluate airborne chemicals of industrial importance which cause sensory irritation in humans; a model was calibrated for the prediction of safe levels of exposure in industry. This model permitted the evaluation of mixtures of airborne chemicals and could be calibrated to predict human response to such mixtures. The development of tolerance to airborne chemical irritants and the cumulative effects of airborne chemical irritants could be investigated with this bioassay system. The development of a valid animal model for pulmonary hypersensitivity and the application of such findings in workers was initiated. Through an animal bioassay which was developed the interaction of inhaled chemicals with DNA can be studied in alveolar macrophages.
NIOSH-Grant; Inhalation-studies; Laboratory-animals; Bioassays; Eye-irritants; Lung-irritants; Respiratory-irritants
Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
Final Grant Report
NTIS Accession No.
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, Terminal Progress Report
University of Pittsburgh, Pittsburgh, Pennsylvania