NIOSHTIC-2 Publications Search
Intraneural connective tissue proliferation of the median nerve in the carpal tunnel.
Castelli-WA; Evans-FG; Diaz-Perez-R; Armstrong-TJ
Department of Anatomy, University of Michigan, Ann Arbor, Michigan, 1984 Jan; :1-16
In order to evaluate the proliferation of the intraneural connective tissue and its intrinsic vasculature, segments were taken from the median nerve from the distal fourth of the right forearm and the carpal tunnel area in 23 embalmed human cadavers. The percentage of the cross sectional area formed by fascicles plus perineuria in the round cross sections of the nerve (proximal to the flexor retinaculum) was significantly greater in both males and females than in the flat cross sections of the nerve within the carpal tunnel. The flattened cross sections of the median nerve obtained from the carpal tunnel exhibited circumscribed laminated masses of fibrous connective tissue. These were identified as Renaut bodies and their presence may indicate abnormal intraneural proliferation of connective tissue as well. The thicker epineurial and perineurial layers of the median nerve within the carpal tunnel probably represents localized areas of subclinical reactive connective tissue hyperplasia. There were no comparable changes in the nerve fascicles of the median nerve proximal to the carpal tunnel. Remarkable proliferation of the intraneural connective tissue was noted in the flattened sections of most nerves.
NIOSH-Grant; Arm-injuries; Hand-injuries; Musculoskeletal-system-disorders; Carpal-tunnel-syndrome; Nervous-system-disorders; Cumulative-trauma-disorders
Industrial & Operations Engr University of Michigan 2260 G G Brown Laboratory Ann Arbor, Mich 48109
Final Grant Report
NTIS Accession No.
Department of Anatomy, University of Michigan, Ann Arbor, Michigan
University of Michigan at Ann Arbor, Ann Arbor, Michigan
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division