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Exposure to mixtures of airborne contaminants.
University of Rochester School of Medicine and Dentistry, Rochester, New York, Final Progress Report 1977 Jan; :1-25
Attempts were made to characterize the response of laboratory animals to particulates carried in the air and to gaseous airborne pollutants, as a preliminary step towards investigation of the effects of a mixture of gaseous and particulate pollutants. Guinea- pigs were exposed fluoride (16984488) at 1.2mg/m3 as fluorspar (7789755) dust of respirable size for 16 weeks or to fluoride at 3.3mg/m3 as hydrogen-fluoride (7664393). The fluoride concentrations were increased in plasma, femur, and feces. Hydrogen- fluoride exposure also increased fluoride levels in the bile and urine. The number of alveolar macrophages was increased on dust exposure whereas the incidence of patchy pneumonitis was decreased on hydrogen-fluoride exposure. Pulmonary edema was produced but only lasted 2 days. All these changes returned to normal after exposure to the fluoride agents was terminated, with the exception of skeletal fluoride levels. No evidence of continuing harmful effects was noted. Studies remain to be conducted of animals exposed to the two pollutants, particulates and gaseous forms, simultaneously.
NIOSH-Grant; Body-distribution; Fluorides; Fluoride-compounds; Airborne-particles; Toxic-gases; Inhalation-studies; Respirable-dust; Pulmonary-system; Laboratory-animals
Radiation Biology & Biophysics University of Rochester Dept of Rad Biol & Biophysics Rochester, N Y 14642
16984-48-8; 7789-75-5; 7664-39-3
Final Grant Report
NTIS Accession No.
University of Rochester School of Medicine and Dentistry, Rochester, New York, Final Progress Report
University of Rochester, Rochester, New York
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division