Surgery during pregnancy and fetal outcome.
Brodsky-JB; Cohen-EN; Brown-BW Jr.; Wu-ML; Whitcher-C
Department of Anesthesiology, Stanford University Medical Center, Stanford, California, 1981 Jan; :1-13
Information was sought on wives of dentists or female dental assistants who underwent surgery during their pregnancies to determine the effects of anesthesia and surgery on fetal outcome. Questionnaires on anesthetic exposure, health history and pregnancy history of the respondent or spouse for 1968 through 1978 were completed by 21,634 male dentists and 21,202 female dental assistants. Anesthesia for surgery was administered to 187 women during the first trimester of gestation and to 100 women during the second trimester. Occupational exposure to inhalation anesthetics either directly (dental assistants) or indirectly (wives of exposed male dentists) was associated with a significant increase in spontaneous abortion rate over a comparison group during both trimesters. Anesthesia for surgery was also associated with increased fetal loss when administered during the first or second trimesters. The number of congenital abnormalities in children born to women who had surgery during pregnancy was not increased. For women surgically exposed to anesthetics and occupationally exposed as well, either directly or indirectly, the risk of spontaneous abortion increased almost three fold above control levels. The authors conclude that elective surgery should be deferred during early pregnancy to minimize potential fetal loss.
NIOSH-Grant; Humans; Reproductive-system-disorders; Dentistry; Dental-laboratories; Reproductive-hazards; Anesthesiology; Epidemiology; Occupational-exposure; Medical-treatment
Anesthesia Stanford University Department of Anesthesia Stanford, Calif 94305
Final Grant Report
NTIS Accession No.
Department of Anesthesiology, Stanford University Medical Center, Stanford, California
Stanford University, Stanford, California